PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function
نویسندگان
چکیده
منابع مشابه
IMMUNOBIOLOGY PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function
Plasmacytoid dendritic cells (pDCs) are considered potential tools or targets for immunotherapy. However, current knowledge concerning methodologies to manipulate their development or function remains limited. Here, we investigated the role of the phosphatidylinositol 3-kinase (PI3K)–protein kinase B (PKB)–mammalian target of rapamycin (mTOR) axis in human pDC development, survival, and functio...
متن کاملPI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Plasmacytoid dendritic cells (pDCs) are considered potential tools or targets for immunotherapy. However, current knowledge concerning methodologies to manipulate their development or function remains limited. Here, we investigated the role of the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mammalian target of rapamycin (mTOR) axis in human pDC development, survival, and functio...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-02-413229